Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP | Zendy

Angela X. Gao | Zendy; Longyan Liao | Zendy; Jeremiah A. Johnson | Zendy

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Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP

Author(s) -

Angela X. Gao,

Longyan Liao,

Jeremiah A. Johnson

Publication year - 2014

Publication title -

acs macro letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.966

H-Index - 92

ISSN - 2161-1653

DOI - 10.1021/mz5004097

Subject(s) - romp , conjugate , peg ratio , nanoparticle , brush , doxorubicin , materials science , polymer chemistry , chemistry , chemical engineering , combinatorial chemistry , nanotechnology , polymer , organic chemistry , polymerization , metathesis , medicine , mathematical analysis , mathematics , finance , economics , surgery , chemotherapy , engineering , composite material

A panel of acid-labile bis-norbornene cross-linkers was synthesized and evaluated for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. An acetal-based cross-linker was identified that, when employed in conjunction with a poly(ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions. A combination of this new cross-linker with a novel doxorubicin (DOX)- branch -PEG macromonomer provided BASPs that simultaneously degrade and release cytotoxic DOX in vitro.

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