Hydrogel Nanoparticles with Thermally Controlled Drug Release | Zendy

Teppei Shirakura | Zendy; Taylor J. Kelson | Zendy; Aniruddha Ray | Zendy; Antonina E. Malyarenko | Zendy; Raoul Kopelman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Hydrogel Nanoparticles with Thermally Controlled Drug Release

Author(s) -

Teppei Shirakura,

Taylor J. Kelson,

Aniruddha Ray,

Antonina E. Malyarenko,

Raoul Kopelman

Publication year - 2014

Publication title -

acs macro letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.966

H-Index - 92

ISSN - 2161-1653

DOI - 10.1021/mz500231e

Subject(s) - endocytosis , cisplatin , nanoparticle , cytotoxicity , drug , biophysics , in vitro , materials science , controlled release , cancer cell , nanotechnology , chemistry , pharmacology , cancer , chemotherapy , cell , biochemistry , medicine , surgery , biology

Improving the therapeutic efficacy and reducing systemic side effects of drugs is an important aspect in chemotherapy. The strategy presented here is the use of cisplatin loaded, temperature-sensitive, hydrogel nanoparticles (CisPt-NPs) and their ability to deliver and release chemodrugs selectively, based on thermal stimuli. The specially synthesized CisPt-NPs show a temperature-dependent increase of cisplatin release, at neutral pH (as in blood and normal tissue), in both the presence and absence of common metallic ions, as well as at the low pH found in lysosomes, where endocytosed NPs often localize. These CisPt-NPs were uptaken by breast cancer MDA-MB-435 cells, via endocytosis, and then mostly localized in the lysosomes. The in vitro cytotoxicity tests show that these CisPt-NPs have a significantly better efficacy at the slightly elevated temperatures. Potential applications are discussed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research