Generating Better Medicines for Cancer | Zendy

Stuart S. Dunn | Zendy; James D. Byrne | Zendy; Jillian L. Perry | Zendy; Kai Chen | Zendy; Joseph M. DeSimone | Zendy

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Generating Better Medicines for Cancer

Author(s) -

Stuart S. Dunn,

James D. Byrne,

Jillian L. Perry,

Kai Chen,

Joseph M. DeSimone

Publication year - 2013

Publication title -

acs macro letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.966

H-Index - 92

ISSN - 2161-1653

DOI - 10.1021/mz400116a

Subject(s) - biocompatibility , nanotechnology , cancer therapy , drug delivery , template , materials science , replication (statistics) , cancer , particle (ecology) , process (computing) , wetting , cancer treatment , biochemical engineering , computer science , medicine , biology , engineering , ecology , virology , metallurgy , composite material , operating system

The complexity of tumor biology warrants tailored drug delivery for overcoming the major challenges faced by cancer therapies. The versatility of the PRINT ® (Particle Replication In Non-wetting Templates) process has enabled the preparation of shape- and size-specific particles with a wide range of chemical compositions and therapeutic cargos. Different particle matrices and drugs may be combined in a plug-and-play approach, such that physico-chemical characteristics of delivery vectors may be optimized for biocompatibility, cargo stability and release, circulation half-life, and efficacy. Thus, the engineering of particles for cancer therapy with specific biophysical behaviors and cellular responses has been demonstrated via the PRINT process.

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