Treatment of Amyotrophic Lateral Sclerosis: Lessons Learned from Many Failures | Zendy

P. Hande Özdi̇nler | Zendy; Richard B. Silverman | Zendy

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Treatment of Amyotrophic Lateral Sclerosis: Lessons Learned from Many Failures

Author(s) -

P. Hande Özdi̇nler,

Richard B. Silverman

Publication year - 2014

Publication title -

acs medicinal chemistry letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.065

H-Index - 66

ISSN - 1948-5875

DOI - 10.1021/ml500404b

Subject(s) - amyotrophic lateral sclerosis , neuroscience , mindset , clinical trial , medicine , motor neuron , drug discovery , physical medicine and rehabilitation , psychology , computer science , disease , bioinformatics , spinal cord , pathology , biology , artificial intelligence

Amyotrophic lateral sclerosis (ALS) is one of the most complex neurodegenerative diseases, involving both cortical and spinal components of motor neuron circuitry and non-neuronal cells that support the motor neurons. There is no effective therapeutic for ALS, and compounds that have extended the lifespan of ALS mouse models have failed in clinical trials. This viewpoint discusses current information regarding the changing views about ALS and what the failures in clinical trials can teach us in the search for an effective treatment. Previous challenges and roadblocks in drug discovery for ALS are noted, and solutions to current limitations are discussed. Learning from the past and moving forward with a new mindset can translate into successful and effective treatment strategies in ALS and other related diseases.

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