EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides | Zendy

Gilles H. Goetz | Zendy; Laurence Philippe | Zendy; Michael J. Shapiro | Zendy

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EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides

Author(s) -

Gilles H. Goetz,

Laurence Philippe,

Michael J. Shapiro

Publication year - 2014

Publication title -

acs medicinal chemistry letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.065

H-Index - 66

ISSN - 1948-5875

DOI - 10.1021/ml500239m

Subject(s) - chromatography , supercritical fluid , supercritical fluid chromatography , chemistry , permeability (electromagnetism) , cyclic peptide , peptide , polarity (international relations) , high performance liquid chromatography , membrane , organic chemistry , biochemistry , cell

Most peptides are generally insufficiently permeable to be used as oral drugs. Designing peptides with improved permeability without reliable permeability monitoring is a challenge. We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a peptide, this technique can be used as a permeability surrogate.

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