Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency | Zendy

Wan Seok Yang | Zendy; Kaoru Shimada | Zendy; Darnelle Delva | Zendy; Milesh M. Patel | Zendy; Egberamwen Ode | Zendy; Rachid Skouta | Zendy; Brent R. Stockwell | Zendy

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Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency

Author(s) -

Wan Seok Yang,

Kaoru Shimada,

Darnelle Delva,

Milesh M. Patel,

Egberamwen Ode,

Rachid Skouta,

Brent R. Stockwell

Publication year - 2011

Publication title -

acs medicinal chemistry letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.065

H-Index - 66

ISSN - 1948-5875

DOI - 10.1021/ml200195s

Subject(s) - microtubule , small molecule , identification (biology) , computational biology , cell growth , tubulin , cancer cell , cancer , chemistry , mechanism of action , potency , microbiology and biotechnology , combinatorial chemistry , biochemistry , biology , in vitro , genetics , botany

We analyzed more than 1 million small molecules with the goal of finding simple synthetic compounds that potently inhibit cancer cell growth. We identified three such compounds with unknown mechanisms of action. Subsequent studies revealed that all three of these small molecules target microtubules. These three scaffolds can serve as templates for developing new microtubule-targeted agents, overcoming the limits of existing microtubule-inhibiting drugs derived from complex natural products.

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