Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups | Zendy

Lionel Maurizi | Zendy; Harender S. Bisht | Zendy; Frédéric Bouyer | Zendy; Nadine Millot | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups

Author(s) -

Lionel Maurizi,

Harender S. Bisht,

Frédéric Bouyer,

Nadine Millot

Publication year - 2009

Publication title -

langmuir

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.042

H-Index - 333

eISSN - 1520-5827

pISSN - 0743-7463

DOI - 10.1021/la901602w

Subject(s) - thiol , nanoparticle , nanotechnology , oxide , term (time) , materials science , iron oxide nanoparticles , chemical engineering , iron oxide , chemistry , organic chemistry , engineering , metallurgy , physics , quantum mechanics

The functionalization of superparamagnetic iron oxide nanoparticles (SPIOs) by meso-2,3-dimercaptosuccinic acid (DMSA) was investigated. Under ambient conditions, the thiol groups from DMSA are not stable and do not allow a direct functionalization without storage in stringent conditions or a chemical regeneration of free thiols. In this study, we have developed a protocol based on poly(ethylene glycol) (PEG) grafting of SPIO prior to DMSA anchoring. We have observed that PEG helps to increase the stability of thiol groups under ambient conditions. The thiol functionalized SPIOs were stable under physiological pH and ionic strength as determined by Ellman's essay and allowed us to graft a thiol reactive fluorescent dye: tetramethylrhodamine-5-maleimide (TMRM).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research