Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors | Zendy

YooJin Ghang | Zendy; Jonathan J. Lloyd | Zendy; Melissa Padilla Moehlig | Zendy; Jessica K. Arguelles | Zendy; Magi Mettry | Zendy; Xing Zhang | Zendy; Ryan R. Julian | Zendy; Quan Cheng | Zendy; Richard J. Hooley | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors

Author(s) -

YooJin Ghang,

Jonathan J. Lloyd,

Melissa Padilla Moehlig,

Jessica K. Arguelles,

Magi Mettry,

Xing Zhang,

Ryan R. Julian,

Quan Cheng,

Richard J. Hooley

Publication year - 2014

Publication title -

langmuir

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.042

H-Index - 333

eISSN - 1520-5827

pISSN - 0743-7463

DOI - 10.1021/la502629d

Subject(s) - bilayer , receptor , molecular recognition , interface (matter) , membrane , chemistry , lipid bilayer , biophysics , nanotechnology , materials science , biochemistry , biology , molecule , organic chemistry , gibbs isotherm

Self-folding deep cavitands embedded in a supported lipid bilayer are capable of recognizing suitably labeled proteins at the bilayer interface. The addition of a choline derived binding "handle" to a number of different proteins allows their selective noncovalent recognition, with association constants on the order of 10(5) M(-1). The proteins are displayed at the water:bilayer interface, and a single binding handle allows recognition of the large, charged protein by a small molecule synthetic receptor via complementary shape and charge interactions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research