Surface-Initiated Polymerization within Mesoporous Silica Spheres for the Modular Design of Charge-Neutral Polymer Particles | Zendy

Markus Müllner | Zendy; Jiwei Cui | Zendy; Ka Fung Noi | Zendy; Sylvia T. Gunawan | Zendy; Frank Caruso | Zendy

Open Access

Surface-Initiated Polymerization within Mesoporous Silica Spheres for the Modular Design of Charge-Neutral Polymer Particles

Author(s) -

Markus Müllner,

Jiwei Cui,

Ka Fung Noi,

Sylvia T. Gunawan,

Frank Caruso

Publication year - 2014

Publication title -

langmuir

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.042

H-Index - 333

eISSN - 1520-5827

pISSN - 0743-7463

DOI - 10.1021/la501324r

Subject(s) - polymerization , polymer , materials science , mesoporous silica , chemical engineering , ethylene glycol , mesoporous material , methacrylate , nanoparticle , copolymer , template , surface modification , polymer chemistry , nanotechnology , chemistry , organic chemistry , composite material , catalysis , engineering

We report a templating approach for the preparation of functional polymer replica particles via surface-initiated polymerization in mesoporous silica templates. Subsequent removal of the template resulted in discrete polymer particles. Furthermore, redox-responsive replica particles could be engineered to disassemble in a reducing environment. Particles, made of poly(methacryloyloxyethyl phosphorylcholine) (PMPC) or poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA), exhibited very low association to human cancer cells (below 5%), which renders the reported charge-neutral polymer particles a modular and versatile class of highly functional carriers with potential applications in drug delivery.

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