Layer-by-Layer Polymer Coating on Discrete Particles of Cubic Lyotropic Liquid Crystalline Dispersions (Cubosomes) | Zendy

Chantelle Driever | Zendy; Xavier Mulet | Zendy; Lynne J. Waddington | Zendy; Almar Postma | Zendy; Helmut Thissen | Zendy; Frank Caruso | Zendy; Calum J. Drummond | Zendy

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Layer-by-Layer Polymer Coating on Discrete Particles of Cubic Lyotropic Liquid Crystalline Dispersions (Cubosomes)

Author(s) -

Chantelle Driever,

Xavier Mulet,

Lynne J. Waddington,

Almar Postma,

Helmut Thissen,

Frank Caruso,

Calum J. Drummond

Publication year - 2013

Publication title -

langmuir

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.042

H-Index - 333

eISSN - 1520-5827

pISSN - 0743-7463

DOI - 10.1021/la401660h

Subject(s) - lyotropic , materials science , polymer , methacrylic acid , chemical engineering , bilayer , layer by layer , methacrylate , layer (electronics) , polyelectrolyte , lyotropic liquid crystal , nanoparticle , dynamic light scattering , nanostructure , copolymer , nanotechnology , liquid crystal , chemistry , composite material , membrane , liquid crystalline , biochemistry , optoelectronics , engineering

Cubic phase lyotropic liquid crystalline colloidal dispersions (cubosomes) were surface-modified with seven polyelectrolyte layers using a layer-by-layer (LbL) approach. The first layer consisted of a copolymer synthesized from methacrylic acid and oleoyl methacrylate for enhanced incorporation within the bilayer of the cubic nanostructure. Six additional layers of poly(L-lysine) and poly(methacrylic acid) were then sequentially added, followed by a washing procedure to remove polymer aggregates from the soft matter particles. Polymer buildup was monitored via microelectrophoresis, dynamic light scattering, and small-angle X-ray scattering. Polymer-coated cubosomes were observed with cryo-transmission electron microscopy. A potential application of the modified nanostructured particles presented in this study is to reduce the burst-release effect associated with drug-loaded cubosomes. The effectiveness of this approach was demonstrated through loading and release results from a model hydrophilic small molecule (fluorescein).

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