Organosilylated Complex [Eu(TTA)3(Bpy-Si)]: A Bifunctional Moiety for the Engeneering of Luminescent Silica-Based Nanoparticles for Bioimaging | Zendy

Adriana Pereira Duarte | Zendy; Léïla Mauline | Zendy; Marie Gressier | Zendy; Jeannette DexpertGhys | Zendy; Christine Roques | Zendy; José Maurício A. Caiut | Zendy; Elenice Deffune | Zendy; Danielle Cardoso Geraldo Maia | Zendy; Iracilda Zeppone Carlos | Zendy; Antonio Ap. Pupim Ferreira | Zendy; Sidney J. L. Ribeiro | Zendy; MarieJoëlle Menu | Zendy

Open Access

Organosilylated Complex [Eu(TTA)₃(Bpy-Si)]: A Bifunctional Moiety for the Engeneering of Luminescent Silica-Based Nanoparticles for Bioimaging

Author(s) -

Adriana Pereira Duarte,

Léïla Mauline,

Marie Gressier,

Jeannette DexpertGhys,

Christine Roques,

José Maurício A. Caiut,

Elenice Deffune,

Danielle Cardoso Geraldo Maia,

Iracilda Zeppone Carlos,

Antonio Ap. Pupim Ferreira,

Sidney J. L. Ribeiro,

MarieJoëlle Menu

Publication year - 2013

Publication title -

langmuir

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.042

H-Index - 333

eISSN - 1520-5827

pISSN - 0743-7463

DOI - 10.1021/la400365c

Subject(s) - bifunctional , mesoporous silica , moiety , luminescence , europium , ligand (biochemistry) , nanoparticle , covalent bond , grafting , chelation , chemistry , materials science , photochemistry , inorganic chemistry , nuclear chemistry , mesoporous material , nanotechnology , organic chemistry , polymer , catalysis , biochemistry , receptor , optoelectronics

A new highly luminescent europium complex with the formula [Eu(TTA)3(Bpy-Si)], where TTA stands for the thenoyltrifluoroacetone, (C4H3S)COCH2COCF3, chelating ligand and Bpy-Si, Bpy-CH2NH(CH2)3Si(OEt)3, is an organosilyldipyridine ligand displaying a triethoxysilyl group as a grafting function has been synthesized and fully characterized. This bifunctional complex has been grafted onto the surface of dense silica nanoparticles (NPs) and on mesoporous silica microparticles as well. The covalent bonding of [Eu(TTA)3(Bpy-Si)] inside uniform Stöber silica nanoparticles was also achieved. The general methodology proposed could be applied to any silica matrix, allowed high grafting ratios that overcome chelate release and the tendency to agglomerate. Luminescent silica-based nanoparticles SiO2-[Eu(TTA)3(Bpy-Si)], with a diameter of 28 ± 2 nm, were successfully tested as a luminescent labels for the imaging of Pseudomonas aeruginosa biofilms. They were also functionalized by a specific monoclonal antibody and subsequently employed for the selective imaging of Escherichia coli bacteria.

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