Polysaccharide Films Built by Simultaneous or Alternate Spray: A Rapid Way to Engineer Biomaterial Surfaces | Zendy

Gwenaëlle Cado | Zendy; Halima Kerdjoudj | Zendy; Armelle Chassepot | Zendy; M. Lefort | Zendy; Karim Benmlih | Zendy; Joseph Hemmerlé | Zendy; J.C. Voegel | Zendy; Loı̈c Jierry | Zendy; Pierre Schaaf | Zendy; Yves Frère | Zendy; Fouzia Boulmedais | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Polysaccharide Films Built by Simultaneous or Alternate Spray: A Rapid Way to Engineer Biomaterial Surfaces

Author(s) -

Gwenaëlle Cado,

Halima Kerdjoudj,

Armelle Chassepot,

M. Lefort,

Karim Benmlih,

Joseph Hemmerlé,

J.C. Voegel,

Loı̈c Jierry,

Pierre Schaaf,

Yves Frère,

Fouzia Boulmedais

Publication year - 2012

Publication title -

langmuir

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.042

H-Index - 333

eISSN - 1520-5827

pISSN - 0743-7463

DOI - 10.1021/la300563s

Subject(s) - biomaterial , biocompatibility , adhesion , chemical engineering , chitosan , chondroitin sulfate , chemistry , surface charge , polysaccharide , hyaluronic acid , cell adhesion , materials science , polymer chemistry , nanotechnology , organic chemistry , biochemistry , glycosaminoglycan , engineering , biology , genetics

We investigated polysaccharide films obtained by simultaneous and alternate spraying of a chitosan (CHI) solution as polycation and hyaluronic acid (HA), alginate (ALG), and chondroitin sulfate (CS) solutions as polyanions. For simultaneous spraying, the film thickness increases linearly with the cumulative spraying time and passes through a maximum for polyanion/CHI molar charge ratios lying between 0.6 and 1.2. The size of polyanion/CHI complexes formed in solution was compared with the simultaneously sprayed film growth rate as a function of the polyanion/CHI molar charge ratio. A good correlation was found. This suggests the importance of polyanion/polycation complexation in the simultaneous spraying process. Depending on the system, the film topography is either liquid-like or granular. Film biocompatibility was evaluated using human gingival fibroblasts. A small or no difference is observed in cell viability and adhesion between the two deposition processes. The CHI/HA system appears to be the best for cell adhesion inducing the clustering of CD44, a cell surface HA receptor, at the membrane of cells. Simultaneous or alternate spraying of CHI/HA appears thus to be a convenient and fast procedure for biomaterial surface modifications.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research