Vibrational Investigation of DODC Cation for Recognition of Guanine Dimeric Hairpin Quadruplex Studied by Satellite Holes | Zendy

JiYen Cheng | Zendy; Sheng-Hsien Lin | Zendy; TaChau Chang | Zendy

Open Access

Vibrational Investigation of DODC Cation for Recognition of Guanine Dimeric Hairpin Quadruplex Studied by Satellite Holes

Author(s) -

JiYen Cheng,

Sheng-Hsien Lin,

TaChau Chang

Publication year - 1998

Publication title -

the journal of physical chemistry b

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.864

H-Index - 392

eISSN - 1520-6106

pISSN - 1520-5207

DOI - 10.1021/jp9820424

Subject(s) - guanine , intercalation (chemistry) , oligonucleotide , g quadruplex , satellite , base pair , crystallography , chemistry , sequence (biology) , stereochemistry , physics , dna , chemical physics , biochemistry , nucleotide , gene , inorganic chemistry , astronomy

We have introduced the satellite hole spectral method to examine the binding sites of 3,3‘-diethyloxadicarbocyanine cation (DODC+) to various guanine-rich oligonucleotides. The satellite hole patterns along with normal mode calculations allow us to determine the interaction of DODC+ with a dimeric hairpin quadruplex formed by sequence d(G4T4G4). Our results are consistent with the groove binding model and eliminate the possibility of intercalation in the base pairs of guanine quartet.

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