Biosensing, Cytotoxicity, and Cellular Uptake Studies of Surface-Modified Gold Nanorods | Zendy

Harshala Parab | Zendy; Hao Ming Chen | Zendy; TsungChing Lai | Zendy; Jing Huang | Zendy; Po Hsun Chen | Zendy; RuShi Liu | Zendy; Michael Hsiao | Zendy; ChungHsuan Chen | Zendy; Din Ping Tsai | Zendy; Y. Hwu | Zendy

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Biosensing, Cytotoxicity, and Cellular Uptake Studies of Surface-Modified Gold Nanorods

Author(s) -

Harshala Parab,

Hao Ming Chen,

TsungChing Lai,

Jing Huang,

Po Hsun Chen,

RuShi Liu,

Michael Hsiao,

ChungHsuan Chen,

Din Ping Tsai,

Y. Hwu

Publication year - 2009

Publication title -

the journal of physical chemistry c

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.401

H-Index - 289

eISSN - 1932-7455

pISSN - 1932-7447

DOI - 10.1021/jp9000169

Subject(s) - nanorod , surface plasmon resonance , biomolecule , nanotechnology , bromide , materials science , colloidal gold , surface charge , surface modification , chemistry , nanoparticle , inorganic chemistry

Herein we report biorecognition studies of protein IgG using biocomapatible gold nanorods as molecular probes. Surface modification of cetyltrimethylammonium bromide (CTAB)-stabilized gold nanorods was carried out by using poly(styrenesulfonate) (PSS) to reduce the toxicity of as-synthesized gold nanorods caused by free CTAB. ζ potential analysis confirmed charge reversal on the surface of gold nanorods caused by the PSS coating. Surface plasmon resonance exhibited by gold nanorods has been employed as a tool for analyzing the binding events for biomolecules. TEM results, showing the aggregation of gold nanorods, in addition to the shift in surface plasmon resonance peak in UV−vis absorption measurements, upon the interaction of biomolecules with gold nanorods, confirmed molecular binding. Morphological changes caused by the cellular uptake of gold nanorods before and after PSS modification have been observed. Cell viability studies using gold nanorods were performed to study the cytotoxic effects of thes...

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