Effects of Sugars on Lipid Bilayers during Dehydration − SAXS/WAXS Measurements and Quantitative Model | Zendy

Thomas Lenné | Zendy; Christopher J. Garvey | Zendy; Karen L. Koster | Zendy; Gary Bryant | Zendy

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Effects of Sugars on Lipid Bilayers during Dehydration − SAXS/WAXS Measurements and Quantitative Model

Author(s) -

Thomas Lenné,

Christopher J. Garvey,

Karen L. Koster,

Gary Bryant

Publication year - 2009

Publication title -

the journal of physical chemistry b

Language(s) - English

Resource type - Journals

eISSN - 1520-6106

pISSN - 1520-5207

DOI - 10.1021/jp808670t

Subject(s) - small angle x ray scattering , dipalmitoylphosphatidylcholine , dehydration , chemistry , phospholipid , bilayer , sugar , lipid bilayer , membrane , crystallography , phase (matter) , chemical engineering , chromatography , scattering , organic chemistry , biochemistry , phosphatidylcholine , physics , optics , engineering

We present an X-ray scattering study of the effects of dehydration on the bilayer and chain-chain repeat spacings of dipalmitoylphosphatidylcholine bilayers in the presence of sugars. The presence of sugars has no effect on the average spacing between the phospholipid chains in either the fluid or gel phase. Using this finding, we establish that for low sugar concentrations only a small amount of sugar exclusion occurs. Under these conditions, the effects of sugars on the membrane transition temperatures can be explained quantitatively by the reduction in hydration repulsion between bilayers due to the presence of the sugars. Specific bonding of sugars to lipid headgroups is not required to explain this effect.

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