Chemical Imaging with Frequency Modulation Coherent Anti-Stokes Raman Scattering Microscopy at the Vibrational Fingerprint Region | Zendy

BiChang Chen | Zendy; Jiha Sung | Zendy; SangHyun Lim | Zendy

Open Access

Chemical Imaging with Frequency Modulation Coherent Anti-Stokes Raman Scattering Microscopy at the Vibrational Fingerprint Region

Author(s) -

BiChang Chen,

Jiha Sung,

SangHyun Lim

Publication year - 2010

Publication title -

the journal of physical chemistry b

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.864

H-Index - 392

eISSN - 1520-6106

pISSN - 1520-5207

DOI - 10.1021/jp104553s

Subject(s) - raman scattering , chemical imaging , microscopy , raman spectroscopy , coherent anti stokes raman spectroscopy , signal (programming language) , optics , modulation (music) , laser , materials science , resolution (logic) , hyperspectral imaging , chemistry , optoelectronics , physics , acoustics , remote sensing , artificial intelligence , computer science , programming language , geology

We present a new coherent anti-Stokes Raman scattering (CARS) method that can perform background-free microscopy and microspectroscopy at the vibrational fingerprint region. Chirped broad-band pulses from a single Ti:sapphire laser generate CARS signals over 800-1700 cm(-1) with a spectral resolution of 20 cm(-1). Fast modulation of the time delay between the pump and Stokes pulses coupled with lock-in signal detection not only removes the nonresonant background but also produces Raman-like CARS signals. Chemical imaging and microspectroscopy are demonstrated with various samples such as edible oils, lipid membranes, skin tissue, and plant cell walls. Systematic studies of the signal generation mechanism and several fundamental aspects are discussed.

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