DNA Detection Method Based on the Two-Dimensional Aggregation and Selective Desorption of Nanoparticle Probes | Zendy

Anne Charrier | Zendy; Nadine Candoni | Zendy; F. Thibaudau | Zendy

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DNA Detection Method Based on the Two-Dimensional Aggregation and Selective Desorption of Nanoparticle Probes

Author(s) -

Anne Charrier,

Nadine Candoni,

F. Thibaudau

Publication year - 2006

Publication title -

the journal of physical chemistry b

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.864

H-Index - 392

eISSN - 1520-6106

pISSN - 1520-5207

DOI - 10.1021/jp061616z

Subject(s) - nanoparticle , desorption , dna , nanotechnology , computational biology , chemistry , materials science , biology , biochemistry , adsorption , organic chemistry

A label-free two-dimensional colorimetric DNA sensor is reported. This sensor is based on the 2D aggregation of oligonucleotide-modified gold nanoparticle probes induced by the molecular hybridization of single-stranded oligonucleotide probes and their complementary single-stranded DNA targets. To detect the aggregation, we have developed a new detection method based on the selective desorption of nonaggregated nanoparticles. We will show here that this detection method is highly specific and allows the quantification of the DNA targets.

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