Open AccessSelective [3 + 2] Huisgen Cycloaddition. Synthesis of Trans-Disubstituted Triazolodiazepines from Aza-Baylis−Hillman Adducts
Author(s) -
Valérie Declerck,
Loı̈c Toupet,
Jean Martínez,
Frédéric Lamaty
Publication year - 2009
Publication title -
the journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/jo802533d
Subject(s) - chemistry , cycloaddition , diastereomer , adduct , 1,3 dipolar cycloaddition , stereochemistry , stereoselectivity , medicinal chemistry , organic chemistry , catalysis
The 1,3-dipolar cycloaddition of linear azido alkynes derived from protected beta-amino esters proceeds via diastereomeric differentiation to provide trans-disubstituted triazolodiazepines in good yields.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom