Open AccessSynthesis of 2(3H)-Furanones via Electrophilic Cyclization
Author(s) -
Ziwei W. Just,
Richard C. Larock
Publication year - 2008
Publication title -
the journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/jo702666j
Subject(s) - electrophile , chemistry , combinatorial chemistry , process (computing) , organic chemistry , computer science , catalysis , programming language
A variety of highly substituted 2(3H)-furanones are readily prepared from 3-alkynoate esters and the corresponding acids via electrophilic cyclization. Successful electrophiles in this process include I2, ICl, and PhSeCl. This highly efficient process proceeds under mild conditions, tolerates various functional groups, and generally provides substituted 2(3H)-furanones in good to excellent yields.
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