Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst | Zendy

Chi Wai Cheung | Zendy; Stephen L. Buchwald | Zendy

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Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

Author(s) -

Chi Wai Cheung,

Stephen L. Buchwald

Publication year - 2014

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo500662s

Subject(s) - chemistry , palladium , halide , aryl , catalysis , hydroxylation , yield (engineering) , ligand (biochemistry) , organic chemistry , phenols , combinatorial chemistry , medicinal chemistry , alkyl , biochemistry , materials science , receptor , metallurgy , enzyme

A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

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