Development of a Suzuki Cross-Coupling Reaction between 2-Azidoarylboronic Pinacolate Esters and Vinyl Triflates To Enable the Synthesis of [2,3]-Fused Indole Heterocycles | Zendy

Navendu Jana | Zendy; Quyen T. Nguyen | Zendy; Tom G. Driver | Zendy

Open Access

Development of a Suzuki Cross-Coupling Reaction between 2-Azidoarylboronic Pinacolate Esters and Vinyl Triflates To Enable the Synthesis of [2,3]-Fused Indole Heterocycles

Author(s) -

Navendu Jana,

Quyen T. Nguyen,

Tom G. Driver

Publication year - 2014

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo500252e

Subject(s) - chemistry , regioselectivity , amination , coupling reaction , indole test , suzuki reaction , organic chemistry , combinatorial chemistry , reaction conditions , catalysis , palladium

The scope and limitations of a Suzuki reaction between 2-azidoarylboronic acid pinacolate esters and vinyl triflates are reported. This cross-coupling reaction enables the regioselective synthesis of indoles after a subsequent Rh(II)2-catalyzed sp(2)-C-H bond amination reaction.

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