Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes | Zendy

Véronique I. Martin | Zendy; John R. Goodell | Zendy; O.J. Ingham | Zendy; John A. Porco | Zendy; Aaron B. Beeler | Zendy

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Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

Author(s) -

Véronique I. Martin,

John R. Goodell,

O.J. Ingham,

John A. Porco,

Aaron B. Beeler

Publication year - 2014

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo500190b

Subject(s) - chemistry , chemotype , continuous flow , microfluidics , flow chemistry , nanotechnology , combinatorial chemistry , photochemistry , biochemical engineering , organic chemistry , chromatography , catalysis , materials science , essential oil , engineering

We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemotypes through multidimensional reaction screening. We will highlight the ability to discretely control wavelengths with optical filters, allowing for control of reaction outcomes.

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