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The structurally conserved lipopolysaccharide core region of many Gram-negative bacteria is composed of trisaccharides containing 4-O-phosphorylated L-glycero-D-manno-heptose (L,D-Hep) units, which act as ligands for antibodies and lectins. The disaccharides Glc-(1→3)-Hep4P Hep-(1→3)-Hep4P and Hep-(1→7)-Hep4P and the branched trisaccharide Glc-(1→3)-[Hep-(1→7)]-Hep4P, respectively, have been synthesized from a methyl heptopyranoside acceptor in less than 10 steps. The synthetic strategy was based on the early introduction of a phosphotriester at position 4 of heptose followed by a regioselective opening of a 6,7-O-(1,1,3,3-tetraisopropyl-1,3-disiloxane-1,3-diyl) group allowing for a straightforward access to glycosylation at position 7. Perbenzylated N-phenyl trifluoroacetimidate glucosyl and heptosyl derivatives served as α-selective glycosyl donors.

journal of organic chemistry

Convergent Synthesis of 4-O-Phosphorylated <scp>l</scp>-glycero-<scp>d</scp>-manno-Heptosyl Lipopolysaccharide Core Oligosaccharides Based on Regioselective Cleavage of a 6,7-O-Tetraisopropyldisiloxane-1,3-diyl Protecting Group

Convergent Synthesis of 4-O-Phosphorylated l-glycero-d-manno-Heptosyl Lipopolysaccharide Core Oligosaccharides Based on Regioselective Cleavage of a 6,7-O-Tetraisopropyldisiloxane-1,3-diyl Protecting Group