Modular Access to N-Substituted cis-3,5-Diaminopiperidines | Zendy

Aurélie Blond | Zendy; Paul Dockerty | Zendy; Raquel Álvarez | Zendy; Serge Turcaud | Zendy; Thomas Lecourt | Zendy; Laurent Micouin | Zendy

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Modular Access to N-Substituted cis-3,5-Diaminopiperidines

Author(s) -

Aurélie Blond,

Paul Dockerty,

Raquel Álvarez,

Serge Turcaud,

Thomas Lecourt,

Laurent Micouin

Publication year - 2013

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo401994y

Subject(s) - hydrogenolysis , reductive amination , bicyclic molecule , chemistry , combinatorial chemistry , hydrazine (antidepressant) , amination , modular design , sequence (biology) , oxidative cleavage , organic chemistry , stereochemistry , computer science , catalysis , biochemistry , programming language

A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-substituted cis-3,5-diaminopiperidines from a readily available bicyclic hydrazine. This new synthetic route provides a simple and general access to RNA-friendly fragments with a good chemical diversity.

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