Microwave-Assisted One-Pot Tandem Reactions for Direct Conversion of Primary Alcohols and Aldehydes to Triazines and Tetrazoles in Aqueous Media | Zendy

JiunJie Shie | Zendy; JimMin Fang | Zendy

Open Access

Microwave-Assisted One-Pot Tandem Reactions for Direct Conversion of Primary Alcohols and Aldehydes to Triazines and Tetrazoles in Aqueous Media

Author(s) -

JiunJie Shie,

JimMin Fang

Publication year - 2007

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo0625352

Subject(s) - chemistry , tandem , microwave irradiation , primary (astronomy) , sodium azide , iodine , aqueous solution , azide , aqueous medium , ammonia , organic chemistry , halide , combinatorial chemistry , catalysis , materials science , physics , astronomy , composite material

A series of primary alcohols and aldehydes were treated with iodine in ammonia water under microwave irradiation to give the intermediate nitriles, which without isolation underwent [2+3] cycloadditions with dicyandiamide and sodium azide to afford high yields of the corresponding triazines and tetrazoles, including the alpha-amino- and dipeptidyl tetrazoles in high optical purity.

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