Vol. 68, 2003 An Effective One-Pot Synthesis of 5-Substituted Tetronic Acids. | Zendy

David Tejedor Aragón | Zendy; Gloria V. López | Zendy; Fernando GarcíaTellado | Zendy; José Juan MarreroTellado | Zendy; Pedro de Armas | Zendy; David Terrero | Zendy

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Vol. 68, 2003 An Effective One-Pot Synthesis of 5-Substituted Tetronic Acids.

Author(s) -

David Tejedor Aragón,

Gloria V. López,

Fernando GarcíaTellado,

José Juan MarreroTellado,

Pedro de Armas,

David Terrero

Publication year - 2003

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo033581u

Subject(s) - notice , citation , altmetrics , computer science , social media , information retrieval , world wide web , library science , political science , law

An expeditious one-pot synthesis of 5-substituted tetronic acids from aldehydes and terminal conjugated alkyne as starting materials is described. The entire process embodies two consecutive chemical events: a catalytic domino reaction to build the 1,3-dioxolane scaffolds 5 and a two-step acid-catalyzed trans-acetalization-lactonization reaction to furnish the tetronic acid derivatives 6.

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