Synthesis of a Sialic Acid Dimer Derivative, 2‘α-O-Benzyl Neu5Ac-α-(2→5)Neu5Gc | Zendy

ChienTai Ren | Zendy; ChienSheng Chen | Zendy; ShihHsiung Wu | Zendy

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Synthesis of a Sialic Acid Dimer Derivative, 2‘α-O-Benzyl Neu5Ac-α-(2→5)Neu5Gc

Author(s) -

ChienTai Ren,

ChienSheng Chen,

ShihHsiung Wu

Publication year - 2002

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo015930v

Subject(s) - chemistry , disaccharide , sialic acid , adduct , dimer , yield (engineering) , derivative (finance) , n acetylneuraminic acid , protecting group , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , biochemistry , materials science , alkyl , economics , financial economics , metallurgy

The preparation of a disaccharide 2, Neu5Ac-alpha-(2-->5)Neu5Gc having a alpha-benzyl protecting group at the reducing end, by the coupling of the easily accessible building units 4 and 5 is described. Subsequent deprotection of the coupling adduct led to the isolation of the target compound 2 in high yield.

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