Efficient and Convenient Nonaqueous Workup Procedure for the Preparation of Arylboronic Esters | Zendy

KenTsung Wong | Zendy; YuhYih Chien | Zendy; YuanLi Liao | Zendy; ChangChih Lin | Zendy; MengYen Chou | Zendy; Mankit Leung | Zendy

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Efficient and Convenient Nonaqueous Workup Procedure for the Preparation of Arylboronic Esters

Author(s) -

KenTsung Wong,

YuhYih Chien,

YuanLi Liao,

ChangChih Lin,

MengYen Chou,

Mankit Leung

Publication year - 2002

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo011073j

Subject(s) - reagent , chemistry , ethylene glycol , toluene , aryl , organic chemistry , combinatorial chemistry , alkyl

An efficient one-pot synthetic protocol for the synthesis of arylboronic esters has been established. The concentrated addition mixture of trimethylborate with aryl Grignard reagents was treated with low molecular weight diols (ethylene glycol, 1,3-propandiol) and toluene, the corresponding arylboronic esters were isolated in a convenient way with high yields. The diols not only serve as water replacement for the workup step, but also as well as the reagent for the preparation of arylboronic esters.

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