Open AccessA direct synthesis of trichodiene
Author(s) -
George A. Kraus,
Philipp Thomas
Publication year - 1986
Publication title -
the journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/jo00354a018
Subject(s) - chemistry , stereochemistry , combinatorial chemistry
The synthesis of trichodiene via the Ireland modification of the Claisen rearrangement is described. The enol ether resulting from the rearrangement functions as a protecting group during two reduction steps. The enol ether diastereomers can be conveniently separated by flash chromatography.
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