Open AccessA Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site
Author(s) -
M. Katharine Holloway,
Jenny M. Wai,
Thomas A. Halgren,
Paul J. Fitzgerald,
Joseph P. Vacca,
Bruce D. Dorsey,
Rhonda B. Levin,
Wayne J. Thompson,
L. Jenny Chen,
S. J. Desolms,
Neil Gaffin,
Arun K. Ghosh,
Elizabeth A. Giuliani,
Samuel Graham,
James P. Guare,
Randall W. Hungate,
Terry A. Lyle,
William M. Sanders,
Thomas J. Tucker,
Mark W. Wiggins,
Catherine M. Wiscount,
Otto W. Woltersdorf,
Steven D. Young,
Paul L. Darke,
Joan A. Zugay
Publication year - 1996
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/jm960144h
Subject(s) - chemistry , protease , a priori and a posteriori , human immunodeficiency virus (hiv) , energy minimization , pharmacology , computational biology , biochemistry , enzyme , computational chemistry , virology , philosophy , epistemology , biology , medicine