Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties | Zendy

David J. Haydon | Zendy; James M. Bennett | Zendy; David R. Brown | Zendy; Ian Collins | Zendy; Greta Galbraith | Zendy; Paul Lancett | Zendy; Rebecca Macdonald | Zendy; Neil R. Stokes | Zendy; Pramod K. Chauhan | Zendy; Jignesh K. Sutariya | Zendy; Narendra Nayal | Zendy; Anil Srivastava | Zendy; Joy Beanland | Zendy; Robyn N. Hall | Zendy; Vincent Henstock | Zendy; Caterioula | Zendy; Chris Rockley | Zendy; Lloyd G. Czaplewski | Zendy

Open Access

Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

Author(s) -

David J. Haydon,

James M. Bennett,

David R. Brown,

Ian Collins,

Greta Galbraith,

Paul Lancett,

Rebecca Macdonald,

Neil R. Stokes,

Pramod K. Chauhan,

Jignesh K. Sutariya,

Narendra Nayal,

Anil Srivastava,

Joy Beanland,

Robyn N. Hall,

Vincent Henstock,

Caterioula,

Chris Rockley,

Lloyd G. Czaplewski

Publication year - 2010

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/jm9016366

Subject(s) - ftsz , chemistry , in vivo , bacterial cell structure , cell division , antibacterial activity , in vitro , bacterial protein , antibacterial agent , cell , drug , alkyl , division (mathematics) , biochemistry , bacteria , combinatorial chemistry , antibiotics , pharmacology , biology , organic chemistry , genetics , gene , arithmetic , mathematics

3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties.

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