Fragment-Based Screening of the Bromodomain of ATAD2 | Zendy

Mary J. Harner | Zendy; Brian A. Chauder | Zendy; Jason Phan | Zendy; Stephen W. Fesik | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Fragment-Based Screening of the Bromodomain of ATAD2

Author(s) -

Mary J. Harner,

Brian A. Chauder,

Jason Phan,

Stephen W. Fesik

Publication year - 2014

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/jm501035j

Subject(s) - bromodomain , fragment (logic) , chemistry , nuclear magnetic resonance spectroscopy , small molecule , stereochemistry , computational biology , combinatorial chemistry , biochemistry , dna , algorithm , biology , computer science , histone

Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research