Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus | Zendy

C. C. Wen | Zendy; YuehHsiung Kuo | Zendy; Jia-Tsrong Jan | Zendy; PoHuang Liang | Zendy; ShengYang Wang | Zendy; Hong-Gi Liu | Zendy; ChingKuo Lee | Zendy; ShangTzen Chang | Zendy; ChihJung Kuo | Zendy; ShoeiSheng Lee | Zendy; Chia-Chung Hou | Zendy; PeiWen Hsiao | Zendy; Shih-Chang Chien | Zendy; LieFen Shyur | Zendy; Ning-Sun Yang | Zendy

Open Access

Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus

Author(s) -

C. C. Wen,

YuehHsiung Kuo,

Jia-Tsrong Jan,

PoHuang Liang,

ShengYang Wang,

Hong-Gi Liu,

ChingKuo Lee,

ShangTzen Chang,

ChihJung Kuo,

ShoeiSheng Lee,

Chia-Chung Hou,

PeiWen Hsiao,

Shih-Chang Chien,

LieFen Shyur,

Ning-Sun Yang

Publication year - 2007

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/jm070295s

Subject(s) - vero cell , chemistry , terpenoid , ec50 , pharmacology , coronavirus , traditional medicine , stereochemistry , in vitro , biochemistry , biology , covid-19 , medicine , disease , pathology , infectious disease (medical specialty)

In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects.

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