Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model. | Zendy

Balu Balasubramanian | Zendy; Denis R. St. Laurent | Zendy; Mark G. Saulnier | Zendy; Byron H. Long | Zendy; Carol Bachand | Zendy; Françis Beaulieu | Zendy; Wendy Clarke | Zendy; M. P. Deshpande | Zendy; Jeffrey T. Eummer | Zendy; Craig R. Fairchild | Zendy; David B. Frennesson | Zendy; Robert Krämer | Zendy; Frank Y. Lee | Zendy; Mikael Mahler | Zendy; Alain Martel | Zendy; B. Narasimhulu Naidu | Zendy; William C. Rose | Zendy; John A. Russell | Zendy; Edward H. Ruediger | Zendy; Carola Solomon | Zendy; Karen M. Stoffan | Zendy; Henry Ν. C. Wong | Zendy; John Wright | Zendy; Kurt Zimmermann | Zendy; Dolatrai M. Vyas | Zendy

Open Access

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model.

Author(s) -

Balu Balasubramanian,

Denis R. St. Laurent,

Mark G. Saulnier,

Byron H. Long,

Carol Bachand,

Françis Beaulieu,

Wendy Clarke,

M. P. Deshpande,

Jeffrey T. Eummer,

Craig R. Fairchild,

David B. Frennesson,

Robert Krämer,

Frank Y. Lee,

Mikael Mahler,

Alain Martel,

B. Narasimhulu Naidu,

William C. Rose,

John A. Russell,

Edward H. Ruediger,

Carola Solomon,

Karen M. Stoffan,

Henry Ν. C. Wong,

John Wright,

Kurt Zimmermann,

Dolatrai M. Vyas

Publication year - 2004

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/jm040089+

Subject(s) - chemistry , topoisomerase , stereochemistry , combinatorial chemistry , chemical synthesis , biochemistry , computational biology , enzyme , in vitro , biology

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