Synthesis, Biological Activity, and Quantitative Structure−Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives | Zendy

Miguel F. Braña | Zendy; Ana Gradillas | Zendy; Ángel M. Gómez | Zendy; Nuria Acero | Zendy; F. Llinares | Zendy; Dolores MuñozMingarro | Zendy; Cristina Abradelo | Zendy; Fernanda Rey-Stolle | Zendy; M. Yuste | Zendy; Joaquín M. Campos Rosa | Zendy; Miguel Á. Gallo | Zendy; Antonio Espinosa | Zendy

Open Access

Synthesis, Biological Activity, and Quantitative Structure−Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives

Author(s) -

Miguel F. Braña,

Ana Gradillas,

Ángel M. Gómez,

Nuria Acero,

F. Llinares,

Dolores MuñozMingarro,

Cristina Abradelo,

Fernanda Rey-Stolle,

M. Yuste,

Joaquín M. Campos Rosa,

Miguel Á. Gallo,

Antonio Espinosa

Publication year - 2004

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/jm0310784

Subject(s) - chemistry , biological activity , structure–activity relationship , stereochemistry , biochemistry , in vitro

A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.

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