Open AccessConformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity.
Author(s) -
Jeewoo Lee,
KeeChung Han,
Ji-Hye Kang,
Larry L. Pearce,
Nancy E. Lewin,
Shunqi Yan,
S. Benzaria,
Marc C. Nicklaus,
Peter M. Blumberg,
Víctor E. Márquez
Publication year - 2003
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/jm030167d
Subject(s) - chemistry , lipophilicity , diacylglycerol kinase , moiety , stereochemistry , combinatorial chemistry , biochemistry , signal transduction , protein kinase c
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