Effects of Caffeic Acid and Cinnamic Acid on Glucose Uptake in Insulin-Resistant Mouse Hepatocytes | Zendy

Dawei Huang | Zendy; SzuChuan Shen | Zendy; James SwiBea Wu | Zendy

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Effects of Caffeic Acid and Cinnamic Acid on Glucose Uptake in Insulin-Resistant Mouse Hepatocytes

Author(s) -

Dawei Huang,

SzuChuan Shen,

James SwiBea Wu

Publication year - 2009

Publication title -

journal of agricultural and food chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.203

H-Index - 297

eISSN - 1520-5118

pISSN - 0021-8561

DOI - 10.1021/jf901376x

Subject(s) - caffeic acid , insulin resistance , insulin , insulin receptor , glycogen synthase , cinnamic acid , glucose transporter , biochemistry , glycogen , chemistry , glucose uptake , biology , medicine , endocrinology , antioxidant

Tumor necrosis factor-alpha was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.

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