Polysaccharides from Dioscorea batatas Induce Tumor Necrosis Factor-α Secretion via Toll-like Receptor 4-Mediated Protein Kinase Signaling Pathways | Zendy

Ju-Yun Liu | Zendy; FengLing Yang | Zendy; ChunPing Lu | Zendy; Yuliang Yang | Zendy; Chi-Luan Wen | Zendy; KuoFeng Hua | Zendy; ShihHsiung Wu | Zendy

Open Access

Polysaccharides from Dioscorea batatas Induce Tumor Necrosis Factor-α Secretion via Toll-like Receptor 4-Mediated Protein Kinase Signaling Pathways

Author(s) -

Ju-Yun Liu,

FengLing Yang,

ChunPing Lu,

Yuliang Yang,

Chi-Luan Wen,

KuoFeng Hua,

ShihHsiung Wu

Publication year - 2008

Publication title -

journal of agricultural and food chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.203

H-Index - 297

eISSN - 1520-5118

pISSN - 0021-8561

DOI - 10.1021/jf8018722

Subject(s) - secretion , toll like receptor , signal transduction , protein kinase a , tumor necrosis factor alpha , microbiology and biotechnology , polysaccharide , receptor , chemistry , dioscorea , kinase , biology , biochemistry , immunology , innate immune system , medicine , pathology , alternative medicine

The bioactive polysaccharides (named ZPF1) from yam ( Dioscorea batatas) were chemically determined, suggesting repeating beta-1,4-mannan as mainly having a feature of acetylation on C2-OH and C3-OH, around 28%. The ZPF1 participated in the stimulation of murine wild-type macrophages predominantly in tumor necrosis factor-alpha (TNFalpha). Toll-like receptor 4 is proved to be one of the cellular receptors in ZPF1-mediated TNFalpha secretion. Reactive oxygen species transmission and PI3-kinase are found necessary for regulating TNFalpha secretion by ZPF1 stimulation. Moreover, we found that extracellular signal-regulated kinase 1/2, Jun N-terminal kinase 1/2, and p38 mitogen-activated protein kinase play important roles in the regulation of TNFalpha secretion in ZPF1-stimulated macrophages.

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