Salicylic Acid sans Aspirin in Animals and Man: Persistence in Fasting and Biosynthesis from Benzoic Acid | Zendy

John R. Paterson | Zendy; Gwendoline Joan Baxter | Zendy; Jaco S. Dreyer | Zendy; John M. Halket | Zendy; Robert Wesley Flynn | Zendy; J. R. Lawrence | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Salicylic Acid sans Aspirin in Animals and Man: Persistence in Fasting and Biosynthesis from Benzoic Acid

Author(s) -

John R. Paterson,

Gwendoline Joan Baxter,

Jaco S. Dreyer,

John M. Halket,

Robert Wesley Flynn,

J. R. Lawrence

Publication year - 2008

Publication title -

journal of agricultural and food chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.203

H-Index - 297

eISSN - 1520-5118

pISSN - 0021-8561

DOI - 10.1021/jf800974z

Subject(s) - salicylic acid , aspirin , biosynthesis , benzoic acid , persistence (discontinuity) , chemistry , biochemistry , enzyme , geotechnical engineering , engineering

Salicylic acid (SA), which is central to defense mechanisms in plants and the principal metabolite of aspirin, occurs naturally in man with higher levels of SA and its urinary metabolite salicyluric acid (SU) in vegetarians overlapping with levels in patients on low-dose aspirin regimens. SA is widely distributed in animal blood. Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy. A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid. The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment. However, that SA appears to be, at least partially, an endogenous compound should lead to reassessment of its role in human (and animal) pathophysiology.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research