Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo | Zendy

Huarong Huang | Zendy; Yan He | Zendy; Xiaoxing Cui | Zendy; Susan Goodin | Zendy; Hong Wang | Zendy; ChengFeng Du | Zendy; Dongli Li | Zendy; Kun Zhang | Zendy; AhNg Tony Kong | Zendy; Robert S. DiPaola | Zendy; Chung S. Yang | Zendy; Allan H. Conney | Zendy; Xi Zheng | Zendy

Open Access

Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo

Author(s) -

Huarong Huang,

Yan He,

Xiaoxing Cui,

Susan Goodin,

Hong Wang,

ChengFeng Du,

Dongli Li,

Kun Zhang,

AhNg Tony Kong,

Robert S. DiPaola,

Chung S. Yang,

Allan H. Conney,

Xi Zheng

Publication year - 2014

Publication title -

journal of agricultural and food chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.203

H-Index - 297

eISSN - 1520-5118

pISSN - 0021-8561

DOI - 10.1021/jf504058f

Subject(s) - prostate cancer , in vivo , apoptosis , cancer research , prostate , cancer , androgen receptor , in vitro , medicine , growth inhibition , cell growth , endocrinology , chemistry , biology , biochemistry , microbiology and biotechnology

In the present study, the effects of δ-tocopherol (δ-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of α-tocopherol (α-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with δ-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of α-T were modest. The strong effects of δ-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that δ-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of α-T. Moreover, δ-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified δ-T as a better form of vitamin E than α-T for future clinical studies of prostate cancer prevention.

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