New Cyclic Peptides from the Seeds of Annona squamosa L. and Their Anti-inflammatory Activities | Zendy

Yuliang Yang | Zendy; Kuo-Feng Hua | Zendy; Pei-Hsuan Chuang | Zendy; Shih-Hsiung Wu | Zendy; KuenYuh Wu | Zendy; FangRong Chang | Zendy; YangChang Wu | Zendy

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New Cyclic Peptides from the Seeds of Annona squamosa L. and Their Anti-inflammatory Activities

Author(s) -

Yuliang Yang,

Kuo-Feng Hua,

Pei-Hsuan Chuang,

Shih-Hsiung Wu,

KuenYuh Wu,

FangRong Chang,

YangChang Wu

Publication year - 2007

Publication title -

journal of agricultural and food chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.203

H-Index - 297

eISSN - 1520-5118

pISSN - 0021-8561

DOI - 10.1021/jf072594w

Subject(s) - annona squamosa , electrospray ionization , cyclic peptide , chemistry , mass spectrometry , anti inflammatory , stereochemistry , lipopolysaccharide , peptide , botany , biochemistry , chromatography , biology , pharmacology , endocrinology

Two new cyclic peptides, cyclosquamosin H ( 1) and I ( 2), together with six known cyclic peptides, squamin A ( 3), squamin B ( 4), cyclosquamosin A ( 6), cyclosquamosin D ( 7), cyclosquamosin E ( 8), and cherimolacyclopeptide B ( 9), were isolated from the seeds of Annona squamosa. All structures were confirmed by 2D nuclear magnetic resonance, chemical evidence, and electrospray ionization-mass spectromotry/mass spectrometry (ESI-MS/MS). Compound 9 was isolated from this plant for the first time. In the anti-inflammatory assay, compound 7 showed an inhibitory effect on the production of pro-inflammatory cytokines within lipopolysaccharide and Pam3Cys-stimulated J774A.1 macrophages.

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