Asymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis | Zendy

Yury Lebedev | Zendy; I. E. Polishchuk | Zendy; Bholanath Maity | Zendy; Miguel Dinis Veloso Guerreiro | Zendy; Luigi Cavallo | Zendy; Magnus Rueping | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Asymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis

Author(s) -

Yury Lebedev,

I. E. Polishchuk,

Bholanath Maity,

Miguel Dinis Veloso Guerreiro,

Luigi Cavallo,

Magnus Rueping

Publication year - 2019

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.9b10364

Subject(s) - chemistry , hydroboration , catalysis , organic chemistry , combinatorial chemistry

A series of methyl aluminum complexes bearing chiral biphenol-type ligands were found to be highly active catalysts in the asymmetric reduction of heterocyclic ketones (S/C = 100-500, ee up to 99%). The protocol is suitable for a wide range of substrates and has a high tolerance to functional groups. The formed 2-heterocyclic-alcohols are valuable building blocks in drug discovery or can be used as ligands in asymmetric catalysis. Isolation and comprehensive characterization of the reaction intermediates support a catalysis cycle proposed by DFT calculations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research