FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases | Zendy

Jinbo Zhu | Zendy; Cally J. E. Haynes | Zendy; Marion Kieffer | Zendy; Jake L. Greenfield | Zendy; Ryan D. Greenhalgh | Zendy; Jonathan R. Nitschke | Zendy; Ulrich F. Keyser | Zendy

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Fe^II₄L₄ Tetrahedron Binds to Nonpaired DNA Bases

Author(s) -

Jinbo Zhu,

Cally J. E. Haynes,

Marion Kieffer,

Jake L. Greenfield,

Ryan D. Greenhalgh,

Jonathan R. Nitschke,

Ulrich F. Keyser

Publication year - 2019

Publication title -

journal of the american chemical society

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.9b03566

Subject(s) - chemistry , dna , fluorescence , tetrahedron , quenching (fluorescence) , base pair , supramolecular chemistry , crystallography , binding site , stereochemistry , crystal structure , biochemistry , physics , quantum mechanics

A water-soluble self-assembled supramolecular Fe II 4 L 4 tetrahedron binds to single stranded DNA, mismatched DNA base pairs, and three-way DNA junctions. Binding of the coordination cage quenches fluorescent labels on the DNA strand, which provides an optical means to detect the interaction and allows the position of the binding site to be gauged with respect to the fluorescent label. Utilizing the quenching and binding properties of the coordination cage, we developed a simple and rapid detection method based on fluorescence quenching to detect unpaired bases in double-stranded DNA.

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