Ruthenium-Catalyzed Redox Isomerizations inside Living Cells | Zendy

Cristian Vidal | Zendy; María TomásGamasa | Zendy; Alejandro GutiérrezGonzález | Zendy; José L. Mascareñas | Zendy

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Ruthenium-Catalyzed Redox Isomerizations inside Living Cells

Author(s) -

Cristian Vidal,

María TomásGamasa,

Alejandro GutiérrezGonzález,

José L. Mascareñas

Publication year - 2019

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.9b00837

Subject(s) - ruthenium , chemistry , isomerization , bioorthogonal chemistry , catalysis , hydride , redox , combinatorial chemistry , allylic rearrangement , biocompatible material , photochemistry , organic chemistry , metal , click chemistry , medicine , biomedical engineering

Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the "in cellulo" generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cells.

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