A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids | Zendy

Matteo Nadai | Zendy; Filippo Doria | Zendy; Matteo Scalabrin | Zendy; Valentina Pirota | Zendy; Vincenzo Grande | Zendy; Greta Bergamaschi | Zendy; Valeria Amendola | Zendy; Fernaldo Richtia Winnerdy | Zendy; Anh Tuân Phan | Zendy; Sara N. Richter | Zendy; Mauro Freccero | Zendy

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A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids

Author(s) -

Matteo Nadai,

Filippo Doria,

Matteo Scalabrin,

Valentina Pirota,

Vincenzo Grande,

Greta Bergamaschi,

Valeria Amendola,

Fernaldo Richtia Winnerdy,

Anh Tuân Phan,

Sara N. Richter,

Mauro Freccero

Publication year - 2018

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.8b05337

Subject(s) - chemistry , combinatorial chemistry , g quadruplex , nucleic acid , selectivity , cleave , dna , förster resonance energy transfer , catalysis , ligand (biochemistry) , stereochemistry , biochemistry , fluorescence , receptor , physics , quantum mechanics

A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS. FRET melting, CD, NMR, gel sequencing, and mass spectrometry experiments highlight a unique and unexpected selectivity in cleaving G-quadruplex sequences. This selectivity relies both on the binding affinity and structural features of the targeted G-quadruplexes.

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