Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex | Zendy

Cristina de la Torre | Zendy; Anita Toscani | Zendy; Cristina MarínHernández | Zendy; Jonathan A. Robson | Zendy; María Carmen Terencio | Zendy; Andrew J. P. White | Zendy; María José Alcaraz | Zendy; James D. E. T. WiltonEly | Zendy; Ramón MartínezMáñez | Zendy; Félix Sancenón | Zendy

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Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex

Author(s) -

Cristina de la Torre,

Anita Toscani,

Cristina MarínHernández,

Jonathan A. Robson,

María Carmen Terencio,

Andrew J. P. White,

María José Alcaraz,

James D. E. T. WiltonEly,

Ramón MartínezMáñez,

Félix Sancenón

Publication year - 2017

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.7b11158

Subject(s) - ex vivo , chemistry , ruthenium , in vivo , carbon monoxide , endogeny , nanotechnology , biophysics , in vitro , biochemistry , catalysis , microbiology and biotechnology , biology , materials science

A two-photon fluorescent probe based on a ruthenium(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpensive synthesis, and displays many advantages over the widely used palladium-based systems.

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