Multistep Conformation Selection in Amyloid Assembly | Zendy

Ming-Chien Hsieh | Zendy; Liang Chen | Zendy; Anil Mehta | Zendy; David G. Lynn | Zendy; Martha A. Grover | Zendy

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Multistep Conformation Selection in Amyloid Assembly

Author(s) -

Ming-Chien Hsieh,

Liang Chen,

Anil Mehta,

David G. Lynn,

Martha A. Grover

Publication year - 2017

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.7b09362

Subject(s) - chemistry , complementarity (molecular biology) , nucleation , amyloid (mycology) , selection (genetic algorithm) , biophysics , computational biology , artificial intelligence , genetics , computer science , inorganic chemistry , organic chemistry , biology

Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facial complementarity is a critical determinant for amyloid nucleation and structural selection.

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