Sensitive and Accurate 13C Kinetic Isotope Effect Measurements Enabled by Polarization Transfer | Zendy

Eugene E. Kwan | Zendy; Yongho Park | Zendy; Harrison A. Besser | Zendy; Thayer L. Anderson | Zendy; Eric N. Jacobsen | Zendy

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Sensitive and Accurate ¹³C Kinetic Isotope Effect Measurements Enabled by Polarization Transfer

Author(s) -

Eugene E. Kwan,

Yongho Park,

Harrison A. Besser,

Thayer L. Anderson,

Eric N. Jacobsen

Publication year - 2016

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.6b10621

Subject(s) - chemistry , kinetic isotope effect , isotope , kinetic energy , protonation , polarization (electrochemistry) , fractionation , isotope fractionation , glycosylation , catalysis , computational chemistry , chemical physics , deuterium , chromatography , organic chemistry , atomic physics , nuclear physics , ion , biochemistry , physics , quantum mechanics

Polarization transfer is demonstrated as a sensitive technique for the measurement of isotopic fractionation of protonated carbons at natural abundance. This method allows kinetic isotope effects (KIEs) to be determined with substantially less material or shorter acquisition time compared with traditional experiments. Computations quantitatively reproduce the KIEs in a Diels-Alder reaction and a catalytic glycosylation. The glycosylation is shown to occur by an effectively concerted mechanism.

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