UV-Induced Proton Transfer between DNA Strands | Zendy

Yuyuan Zhang | Zendy; Kimberly de La Harpe | Zendy; Ashley A. Beckstead | Zendy; Roberto Improta | Zendy; Bern Kohler | Zendy

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UV-Induced Proton Transfer between DNA Strands

Author(s) -

Yuyuan Zhang,

Kimberly de La Harpe,

Ashley A. Beckstead,

Roberto Improta,

Bern Kohler

Publication year - 2015

Publication title -

journal of the american chemical society

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.5b03914

Subject(s) - chemistry , photoexcitation , excited state , tautomer , electron transfer , photochemistry , picosecond , proton coupled electron transfer , proton , radical ion , radical , base pair , recombination , ion , dna , atomic physics , stereochemistry , laser , biochemistry , physics , organic chemistry , quantum mechanics , optics , gene

UV radiation creates excited states in DNA that lead to mutagenic photoproducts. Photoexcitation of single-stranded DNA can transfer an electron between stacked bases, but the fate of excited states in the double helix has been intensely debated. Here, photoinduced interstrand proton transfer (PT) triggered by intrastrand electron transfer (ET) is detected for the first time by time-resolved vibrational spectroscopy and quantum mechanical calculations. Long-lived excited states are shown to be oppositely charged base pair radical ions. In two of the duplexes, the base pair radical anions are present as tautomers formed by interstrand PT. Charge recombination occurs on the picosecond time scale preventing the accumulation of damaging radicals or mutagenic tautomers.

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