Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry | Zendy

Xhenti Ferhati | Zendy; Ester JiménezMoreno | Zendy; Emily Hoyt | Zendy; Giulia Salluce | Zendy; Mar Cabeza-Cabrerizo | Zendy; Claudio D. Navo | Zendy; Ismael Compañón | Zendy; Padma Akkapeddi | Zendy; María João Matos | Zendy; Noelia Salaverri | Zendy; Pablo Garrido | Zendy; Alfredo Martı́nez | Zendy; Víctor Laserna | Zendy; Thomas V. Murray | Zendy; Gonzalo JiménezOsés | Zendy; Peter Ravn | Zendy; Gonçalo J. L. Bernardes | Zendy; Francisco Corzana | Zendy

Open Access

Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry

Author(s) -

Xhenti Ferhati,

Ester JiménezMoreno,

Emily Hoyt,

Giulia Salluce,

Mar Cabeza-Cabrerizo,

Claudio D. Navo,

Ismael Compañón,

Padma Akkapeddi,

María João Matos,

Noelia Salaverri,

Pablo Garrido,

Alfredo Martı́nez,

Víctor Laserna,

Thomas V. Murray,

Gonzalo JiménezOsés,

Peter Ravn,

Gonçalo J. L. Bernardes,

Francisco Corzana

Publication year - 2022

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.1c07675

Subject(s) - chemistry , bioconjugation , linker , conjugate , trastuzumab , combinatorial chemistry , maleimide , succinimide , cancer cell , stereochemistry , biochemistry , cancer , organic chemistry , breast cancer , medicine , mathematical analysis , mathematics , computer science , operating system

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